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Profile - Letrozole Just a quick write up on a soon to be added compound to our brand Letrozole is a powerful Aromatase Inhibitor that was developed to fight breast cancer. For athletes and bodybuilders, it is a drug used to combat the estrogenic side effects of anabolic steroids water-retention, acne and gynocomastia. It will also raise testosterone levels because of the lowered estrogen in the body. Side effects from Letrozole include a lowered sex drive and continuous use can lead to lowered lipid function and an impaired immune system. Femara®(generic name is letrozole) is a new drug developed for the treatment of advanced breast cancer in women. Femara is the second in a new class of third-generation selective oral aromatase inhibitors.. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body the progression ...

Fasting & Meal Timing

Is breakfast good beneficial or not? Well, I've not come to the conclusion that... It depends. You see a common problem people within the fitness industry suffer from is adrenal fatigue, if you suffer from adrenal fatigue you will not make enough cortisol and this makes it harder to maintain normal blood sugar levels. If you eat a breakfast, between say 6-8AM this can help with this issue, thebenefit of this can last up to approximately 10AM, this is where we get into the realm of balance and passing this should be avoided for health purposes. As mentioned above evening protein intake is important, but then I also recommend periods of fasting for at the most 12 hours with 10 hours being the ideal minimum to support processes such as insulin sensitivity, autophagy and more. It is true that carbohydrates in the morning and post-workout are less likely to be stored as fat.  So here really, the choice is yours, you either can skip it and hav...

Pre & Post Nutrition

As far as pre and post workout goes, I advise to eat within a few hours either side, up to 2 hours  either side is still shown to have the same benefits, less so past 3, plus some like myself use intra  drinks to support the peri nutrition further, I personally drink milk throughout my workout, this has  the benefits of giving me additional electrolytes etc and supporting the intensity and length of my  training, plus carbohydrates during a workout can reduce protein degradation but also blunt AMPK  mediated inhibition of mTOR.  There is enough support to show benefits in taking both protein and carbohydrates throughout the process of pre, intra and post. Again this echos the above that carbohydrates reduce protein  degradation and can work together for increasing protein synthesis and causing the greatest activation of mTOR. www.genesis-ugl.com www.genesis-board.com

Steroids - Safety, Age, Visually

Random question I've received on steroids, the questions simplified, are steroids safe, how can you  tell visually if somebody is using steroids, can you hide it and when is the earliest you can use it? Injectable steroids are very safe, the side effects are exaggerated, oral steroids damage the liver and should be avoided. I don't go out of my way to recommend steroids although I'm willing to help someone if they decided they wanted to take steroids. The traps, neck and delts have a naturally high density of andogen receptors, they blow up the most when someone starts taking steroids. The calves have a very low androgen receptor density, this is why steroids don't help very much with calf growth. If you see someone with an usually thick neck, big traps and round delts you're most likely looking at a steroid user. A steroid using man vs a natural man is basically the same as a man vs a woman, the visual difference can be that dramatic. A sexual ...

Steroids - Temporary Gains?

Random question I've received on gear, the question simplified, is do steroids only cause temporary  gains? Well, the answer is yes and no. If you pass your genetic limit for muscle, some of what you gain will be temporary once cycled off, however, it is possible to keep everything up to the point of the genetic limit providing your training and diet is on point. Where I answered no, they are not temporary is a little harder to explain. You see steroids increase satellite cell proliferation, as does training. Satellite cells donate nuclei to muscle cells which allows them to grow/hypertrophy. During de-training the number of nuclei doesn't decrease, this means that when you start training again you'll grow much faster than you did the first time because you don't have to wait for satellite cells to donate nuclei, the nuclei are already present. Steroids will help you reach your genetic limit faster than usual, this is why beginner cy...

Food GI

Random question I've received on GI, the question simplified, does the glycemic index make any  difference on body composition or health?  Glycemic index really doesn't make much of a difference to your physique whether you eat low or high GI carbs but this doesn't mean you should throw all caution to the wind, low GI carbs are much better for your health because they don't raise/spike your blood glucose levels as high. Glucose is an extremely destructive molecule, this is why your body keeps your blood glucose levels within a very narrow range, when your blood glucose levels are too high it damages almost every tissue in your body (especially your eyes, there's a very good reason why almost every type 2 diabetic on the planet wears glasses or contact lenses). So although GI makes very little difference in terms of your physique this doesn't mean that you shouldn't care about GI at all, low GI carbs are much healthier. www.genesi...

Soft Drinks

Random question I've received on drinks, the question simplified, Is drinking soft drinks (like diet  coke) okay, along with tea or coffee?  I don't actually recommend soft drinks like diet coke, Too much phosphorus in soft drinks and not enough calcium/magnesium/potassium. Tea contains too much flouride, which can cause problems such as a reduced thyroid and coffee can cause issues, caffeine isn't harmless as people believe but it's not detrimental either. If you having a drink and want it sweetened, I would recommend Stevia, it causes less problems then other sweeteners, I would feed aspartme to my dog. A drink I would recommend, although not amazingly beneficial due to caloric intake etc is orange juice, but this should be drunk with a straw to avoid vitamin C coming into contact with your teeth, Vitamin C is not good for your teeth and I have no idea why they make vitamin C chewables for people especially children, argh. Sayi...

Push Ups

Random question I've received on push ups, the question simplified, are push ups better then the  bench press?  Weighted push-ups are a suitable alternative, in fact I believe weighted push-ups are actually better than bench press due to the fact that push-ups are a closed chain exercise while bench press is an open chain exercise. The comparison between push-ups and bench press is basically the same as the comparison between pull-ups (closed chain) and lat pull downs (open chain). Where the problem lies is that push ups can be hard to add weight to over time, one way around this is to alter the repetition range used for the push ups, this shouldn't cause many issues as it's only one exercise but non the less, if your able to increase the weight within a more efficient hypertrophy range then this would be ideal, once you can't do it within this range unless you actually include them both together, the bench press will take over.

Anti E

Random question I've received on Anti E's, should I take an Anti E? Moststeroid users within the group would or at least should know how Anti E's work and yes they taking letro without steroids will increase testosterone and reduce estrogen, many people take letrozole by itself, it gives a natural lifter a slight advantage. For a dosage, I would recommend half a tablet, approximately 1.25mg per week, any more then this for a natural and you could begin to run into problems such as sex drive etc.  Now I don't directly recommend women take an Anti E, If a woman takes letrozole she will lose a lot of water weight because estrogen promotes water retention. Her fat storage profile will also change, however it won't necessarily be for the better, she'll lose fat from her face, breasts, thighs, ass etc and start shifting toward a make fat distribution, i.e more fat around the midsection.

Vegetarianism

Random question I've received on Vegetarianism, are we biologically designed to be Vegetarians? The idea of us being designed as vegetarians is a load of nonsense, without animal food sources we'd die, it's impossible to get vitamin B12 from plant sources, our ancestors would have all died out if they didn't eat animals. Some examples to illustrate the point: - Iron is better absorbed from animal foods - Vitamin A from animal foods is better absorbed and much more potent on a weight for weight basis - Vitamin K from animal foods is better absorbed and much more potent on a weight for weight basis - Vitamin B12 can only be obtained form animal foods, without animal foods our ancestors wouldhave died - Protein from animal foods is much higher quality than protein from plant foods - Long chain polyunsaturated essential fats (DHA, AA) are easily obtained from animal foods and seafood - The short chain polyunsaturated essential fats (LA,...

Product Breakdown - Genesis UK - Cialis

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Product Breakdown - Genesis UK - Cialis Tadalafil / Cialis 25 x 20mg Tablets Active Half Time 17.5 Hours MG of Product 20mg Average Dosage 5-20mg PRN Amount of Tablet 25 Tablets --- Cialis (Tadalafil) TLDR Cialis (Tadalifil citrate), a phosphodiesterase type 5 inhibitor, is used to treat erectile dysfunction (ED) and decreased libido in males. Cialis works by aiding relaxation of blood vessels and increasing blood flow in the penis during sexual arousal, resulting in improved erectile function. Cialis is much longer lasting than Viagra. Effects can be felt anywhere between 36-48 hours. Cialis (Tadalafil) Overview Tadalafil is one of the more popular erectile dysfunction (ED) medications on the market and is most commonly associated with the brand name Cialis. Released by GlaxoSmithKline in 2003 and now owned by Eli Lilly, Cialis is very similar to the popular ED medication Viagra with the biggest difference being the drug’s active life. Cialis will produce erections ...

Product Breakdown - Genesis UK - Clomid

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Product Breakdown - Genesis UK - Clomid   Clomid / Clomifene Citrate  50 X 20mg Tablets Active Half Time 6 Days MG of Product 20mg Average Dosage 50mg Daily Amount of Tablet 50 Tablets --- Clomid (Clomiphene Citrate) TLDR Clomid was one of the original drugs used in post-cycle-therapy to stave off gynocomastia and raise the body’s natural testosterone levels. It is not an anabolic steroid, but a prescription drug generally prescribed to women as a fertility aid. This is due to the fact that clomiphene citrate shows a pronounced ability to stimulate ovulation. This is accomplished by blocking/minimizing the effects of estrogen in the body. To be more specific Clomid is chemically a synthetic estrogen with both agonist/antagonist properties. In certain target tissues it can block the ability of estrogen to bind with its corresponding receptor. Its clinical use is therefore to oppose the negative feedback of estrogens on the hypothalamic-pituitary-ovarian axis, whi...

Product Breakdown - Genesis UK - Nolvadex

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Product Breakdown - Genesis UK - Nolvadex Nolvadex / Tamoxifen / Nolva 50 X 20mg Tablets Active Half Time 5-7 Days MG of Product 20mg Average Dosage 20mg Daily Amount of Tablet 50 Tablets --- Nolvadex (Tamoxifen Citrate) TLDR Nolvadex is an oral anti-estrogen/estrogen antagonist prescription drug. Nolvadex is commonly referred to as an anti-estrogen, but technically it is more of an estrogen antagonist. An estrogen antagonist has a unique way of preventing estrogen activity. What it does is to compete with estrogen at the receptor sites, occupying it so that estrogen cannot bind with it. Nolvadex is an anticancer drug which is reportedly effective in treating breast cancer, particularly the kind that is induced by estrogen. Its other therapeutic uses include reduction of the risk of invasive breast cancer following surgery and radiation therapy for ductal carcinoma in situ. Nolvadex is also used as preventive drug. It is prescribed in women who are at high risk of developing breast...

Product Breakdown - Genesis UK - Winstrol

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Product Breakdown - Genesis UK - Winstrol Stanozolol / Winstrol / Win / Winnie 50 X 50mg Tablets Active Half Time 9 hours MG of Product 50mg Average Dosage 50-100mg Daily Amount of Tablet 50 Tablets --- Winstrol (Stanaozolol) TLDR Stanozolol (also known as winstrol) is a 17-alpha-alkylated derivative of dihydrotestosterone (DHT) with low androgenic qualities yet highly anabolic. It was first developed in 1962 by American global pharmaceutical company Sterling-Winthrop Laboratories to increase lymphocyte count and CD8+ cell numbers, but to decrease CD4+ and CD3+ in postmenopausal women using it for osteoporosis. This effect would plausibly be useful for treatment of autoimmune disorders. Winstrol is useful in treatment of hereditary angioedema. It also influences some immunological processes. Now stanozolol is produced for sale in two forms: tablets and injections. Stanozolol is the second most widely used oral steroid, succeeded in popularity only by methandienone. Stanozolol tablets h...